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Structure paper

TitleBiomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies.
Journal, issue, pagesJ. Mol. Biol., Vol. 433, Page 167099-167099, Year 2021
Publish dateJan 16, 2020 (structure data deposition date)
AuthorsBorenstein-Katz, A. / Warszawski, S. / Amon, R. / Eilon, M. / Cohen-Dvashi, H. / Leviatan Ben-Arye, S. / Tasnima, N. / Yu, H. / Chen, X. / Padler-Karavani, V. ...Borenstein-Katz, A. / Warszawski, S. / Amon, R. / Eilon, M. / Cohen-Dvashi, H. / Leviatan Ben-Arye, S. / Tasnima, N. / Yu, H. / Chen, X. / Padler-Karavani, V. / Fleishman, S.J. / Diskin, R.
External linksJ. Mol. Biol. / PubMed:34119488
MethodsX-ray diffraction
Resolution1.42 - 2.41 Å
Structure data

PDB-6xtg:
Ab 1116NS19.9 bound to CA19-9
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-6xud:
Apo Ab 1116NS19.9
Method: X-RAY DIFFRACTION / Resolution: 1.51 Å

PDB-6xuk:
AbLIFT design 15 of Ab 1116NS19.9
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

PDB-6xul:
Apo Ab 5b1
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

PDB-6xun:
Ab 5b1 bound to CA19-9
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / Pancreatic cancer / CA19-9 binder / Diagnosis / Immunotherapy reagent / in-silico optimized antibody / immunotherapeutic reagent / Immunotheraeutic agent

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