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TitleProtein-Protein Interaction Inhibitor of SRPKs Alters the Splicing Isoforms of VEGF and Inhibits Angiogenesis.
Journal, issue, pagesIscience, Vol. 24, Page 102423-102423, Year 2021
Publish dateOct 27, 2020 (structure data deposition date)
AuthorsLi, Q. / Zeng, C. / Liu, H. / Yung, K.W.Y. / Chen, C. / Xie, Q. / Zhang, Y. / Wan, S.W.C. / Mak, B.S.W. / Xia, J. ...Li, Q. / Zeng, C. / Liu, H. / Yung, K.W.Y. / Chen, C. / Xie, Q. / Zhang, Y. / Wan, S.W.C. / Mak, B.S.W. / Xia, J. / Xiong, S. / Ngo, J.C.K.
External linksIscience / PubMed:33997701
MethodsX-ray diffraction
Resolution2.05 Å
Structure data

PDB-7dd1:
Crystal structure of SRPK1 in complex with a peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • peptide display vector fth1 (others)
KeywordsTRANSFERASE / RNA splicing / kinase inhibitor / Peptide drug

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