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Structure paper

TitleReenacting the Birth of a Function: Functional Divergence of HIUases and Transthyretins as Inferred by Evolutionary and Biophysical Studies.
Journal, issue, pagesJ. Mol. Evol., Vol. 89, Page 370-383, Year 2021
Publish dateOct 6, 2020 (structure data deposition date)
AuthorsCarrijo de Oliveira, L. / Figueiredo Costa, M.A. / Goncalves Pedersolli, N. / Heleno Batista, F.A. / Migliorini Figueira, A.C. / Salgado Ferreira, R. / Alves Pinto Nagem, R. / Alves Nahum, L. / Bleicher, L.
External linksJ. Mol. Evol. / PubMed:33956179
MethodsX-ray diffraction
Resolution1.46 - 1.55 Å
Structure data

PDB-7kcn:
Reconstructed ancestor of HIUases and Transthyretins
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-7kjj:
Reconstructed ancestor of HIUases and Transthyretins
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-T44:
3,5,3',5'-TETRAIODO-L-THYRONINE / hormone*YM

Source
  • synthetic construct (others)
  • unidentified (others)
KeywordsUNKNOWN FUNCTION / probably a 5-hydroxyisourate hydrolase / TRANSPORT PROTEIN / HORMONE TRANSPORT

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