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TitleSelection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.
Journal, issue, pagesNat Commun, Vol. 12, Page 2547-2547, Year 2021
Publish dateSep 3, 2019 (structure data deposition date)
AuthorsShi, X. / Wan, Y. / Wang, N. / Xiang, J. / Wang, T. / Yang, X. / Wang, J. / Dong, X. / Dong, L. / Yan, L. ...Shi, X. / Wan, Y. / Wang, N. / Xiang, J. / Wang, T. / Yang, X. / Wang, J. / Dong, X. / Dong, L. / Yan, L. / Li, Y. / Liu, L. / Hou, S. / Zhong, Z. / Wilson, I.A. / Yang, B. / Yang, G. / Lerner, R.A.
External linksNat Commun / PubMed:33953162
MethodsX-ray diffraction
Resolution2.2 - 2.79 Å
Structure data

PDB-6kva:
Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6kvf:
Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody-Antigen Complex / CXCR2

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