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Structure paper

TitleDNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.
Journal, issue, pagesNat Commun, Vol. 12, Page 2490-2490, Year 2021
Publish dateFeb 5, 2021 (structure data deposition date)
AuthorsRen, W. / Fan, H. / Grimm, S.A. / Kim, J.J. / Li, L. / Guo, Y. / Petell, C.J. / Tan, X.F. / Zhang, Z.M. / Coan, J.P. ...Ren, W. / Fan, H. / Grimm, S.A. / Kim, J.J. / Li, L. / Guo, Y. / Petell, C.J. / Tan, X.F. / Zhang, Z.M. / Coan, J.P. / Yin, J. / Kim, D.I. / Gao, L. / Cai, L. / Khudaverdyan, N. / Cetin, B. / Patel, D.J. / Wang, Y. / Cui, Q. / Strahl, B.D. / Gozani, O. / Miller, K.M. / O'Leary, S.E. / Wade, P.A. / Wang, G.G. / Song, J.
External linksNat Commun / PubMed:33941775
MethodsX-ray diffraction
Resolution2.647 - 2.798 Å
Structure data

PDB-7lmk:
Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me3
Method: X-RAY DIFFRACTION / Resolution: 2.647 Å

PDB-7lmm:
Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me2
Method: X-RAY DIFFRACTION / Resolution: 2.798 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • bos taurus (domestic cattle)
  • homo sapiens (human)
KeywordsTRANSFERASE / DNA methylation / DNA methyltransferase 1 / Histone modification / Allosteric regulation

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