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| Title | Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 64, Page 6329-6357, Year 2021 |
| Publish date | Jan 26, 2021 (structure data deposition date) |
 Authors | Lapointe, G. / Skepper, C.K. / Holder, L.M. / Armstrong, D. / Bellamacina, C. / Blais, J. / Bussiere, D. / Bian, J. / Cepura, C. / Chan, H. ...Lapointe, G. / Skepper, C.K. / Holder, L.M. / Armstrong, D. / Bellamacina, C. / Blais, J. / Bussiere, D. / Bian, J. / Cepura, C. / Chan, H. / Dean, C.R. / De Pascale, G. / Dhumale, B. / Fisher, L.M. / Fulsunder, M. / Kantariya, B. / Kim, J. / King, S. / Kossy, L. / Kulkarni, U. / Lakshman, J. / Leeds, J.A. / Ling, X. / Lvov, A. / Ma, S. / Malekar, S. / McKenney, D. / Mergo, W. / Metzger, L. / Mhaske, K. / Moser, H.E. / Mostafavi, M. / Namballa, S. / Noeske, J. / Osborne, C. / Patel, A. / Patel, D. / Patel, T. / Piechon, P. / Polyakov, V. / Prajapati, K. / Prosen, K.R. / Reck, F. / Richie, D.L. / Sanderson, M.R. / Satasia, S. / Savani, B. / Selvarajah, J. / Sethuraman, V. / Shu, W. / Tashiro, K. / Thompson, K.V. / Vaarla, K. / Vala, L. / Veselkov, D.A. / Vo, J. / Vora, B. / Wagner, T. / Wedel, L. / Williams, S.L. / Yendluri, S. / Yue, Q. / Yifru, A. / Zhang, Y. / Rivkin, A. |
 External links | J. Med. Chem. / PubMed:33929852 |
| Methods | X-ray diffraction |
| Resolution | 3.3 Å |
| Structure data |  PDB-7lhz: |
| Chemicals |  ChemComp-MPD:  ChemComp-MG:  ChemComp-Y21:  ChemComp-HOH: |
| Source |
|
 Keywords | ISOMERASE/DNA/INHIBITOR / Gyrase / DNA topoisomerase / ParC / ParE / ISOMERASE-DNA-INHIBITOR complex |
klebsiella pneumoniae 342 (bacteria)