|Title||The structure of a virus-encoded nucleosome.|
|Journal, issue, pages||Nat Struct Mol Biol, Vol. 28, Issue 5, Page 413-417, Year 2021|
|Publish date||Apr 29, 2021|
|Authors||Marco Igor Valencia-Sánchez / Stephen Abini-Agbomson / Miao Wang / Rachel Lee / Nikita Vasilyev / Jenny Zhang / Pablo De Ioannes / Bernard La Scola / Paul Talbert / Steve Henikoff / Evgeny Nudler / Albert Erives / Karim-Jean Armache /|
|PubMed Abstract||Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to ...Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.|
|External links||Nat Struct Mol Biol / PubMed:33927388 / PubMed Central|
|Methods||EM (single particle)|
|Resolution||3.4 - 4.5 Å|
|Keywords||STRUCTURAL PROTEIN/DNA / STRUCTURAL PROTEIN / STRUCTURAL PROTEIN-DNA complex|
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