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Structure paper

TitleCancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Journal, issue, pagesInt J Nanomedicine, Vol. 16, Page 2833-2847, Year 2021
Publish dateJun 15, 2018 (structure data deposition date)
AuthorsSui, M. / Xiong, M. / Li, Y. / Zhou, Q. / Shen, X. / Jia, D. / Gou, M. / Sun, Q.
External linksInt J Nanomedicine / PubMed:33883894
MethodsX-ray diffraction
Resolution2.3 - 2.7 Å
Structure data

PDB-6a38:
MVM NS2 NES in complex with CRM1-Ran-RanBP1
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-6a3a:
MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6a3b:
MVM NES mutant Nm13 in complex with CRM1-Ran-RanBP1
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-6a3c:
MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-6a3e:
MVM NES mutant Nm15 in complex with CRM1-Ran-RanBP1
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-9vm1:
MVM NS2 mutant Nm42 in complex with CRM1-Ran-RanBP1
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-NO3:
NITRATE ION

Source
  • homo sapiens (human)
  • saccharomyces cerevisiae (brewer's yeast)
  • minute virus of mice
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
  • saccharomyces cerevisiae s288c (yeast)
KeywordsTRANSPORT PROTEIN / nuclear export / complex / mutant / inhibitor

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