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TitleThe tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
Journal, issue, pagesImmunity, Vol. 54, Page 660-672.e9, Year 2021
Publish dateApr 2, 2020 (structure data deposition date)
AuthorsSaxton, R.A. / Henneberg, L.T. / Calafiore, M. / Su, L. / Jude, K.M. / Hanash, A.M. / Garcia, K.C.
External linksImmunity / PubMed:33852830
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6weo:
IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsCYTOKINE / Interleukin / Receptor / Signaling

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