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TitleBroad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
Journal, issue, pagesJ. Exp. Med., Vol. 218, Year 2021
Publish dateFeb 18, 2021 (structure data deposition date)
AuthorsAgudelo, M. / Palus, M. / Keeffe, J.R. / Bianchini, F. / Svoboda, P. / Salat, J. / Peace, A. / Gazumyan, A. / Cipolla, M. / Kapoor, T. ...Agudelo, M. / Palus, M. / Keeffe, J.R. / Bianchini, F. / Svoboda, P. / Salat, J. / Peace, A. / Gazumyan, A. / Cipolla, M. / Kapoor, T. / Guidetti, F. / Yao, K.H. / Elsterova, J. / Teislerova, D. / Chrdle, A. / Honig, V. / Oliveira, T. / West, A.P. / Lee, Y.E. / Rice, C.M. / MacDonald, M.R. / Bjorkman, P.J. / Ruzek, D. / Robbiani, D.F. / Nussenzweig, M.C.
External linksJ. Exp. Med. / PubMed:33831141
MethodsX-ray diffraction
Resolution1.86 - 2.35 Å
Structure data

PDB-7lse:
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Far Eastern Subtype)
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-7lsf:
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Western Subtype)
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-7lsg:
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Siberian Subtype)
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
  • tick-borne encephalitis virus far eastern subtype
  • tick-borne encephalitis virus (western subtype)
  • tick-borne encephalitis virus
KeywordsIMMUNE SYSTEM/VIRAL PROTEIN / Tick-borne encephalitis virus / antibody / EDIII / TBEV / IMMUNE SYSTEM / IMMUNE SYSTEM-VIRAL PROTEIN complex

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