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TitleDesign, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 4903-4912, Year 2021
Publish dateDec 19, 2019 (structure data deposition date)
AuthorsGambini, L. / Udompholkul, P. / Baggio, C. / Muralidharan, A. / Kenjic, N. / Assar, Z. / Perry, J.J.P. / Pellecchia, M.
External linksJ. Med. Chem. / PubMed:33797903
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-6vbx:
Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsAPOPTOSIS / MCL-1 / 138E12 peptide / Lys-covalent antagonists

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