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TitleCell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Journal, issue, pagesSci Adv, Vol. 7, Year 2021
Publish dateJun 25, 2020 (structure data deposition date)
AuthorsPannecoucke, E. / Van Trimpont, M. / Desmet, J. / Pieters, T. / Reunes, L. / Demoen, L. / Vuylsteke, M. / Loverix, S. / Vandenbroucke, K. / Alard, P. ...Pannecoucke, E. / Van Trimpont, M. / Desmet, J. / Pieters, T. / Reunes, L. / Demoen, L. / Vuylsteke, M. / Loverix, S. / Vandenbroucke, K. / Alard, P. / Henderikx, P. / Deroo, S. / Baatz, F. / Lorent, E. / Thiolloy, S. / Somers, K. / McGrath, Y. / Van Vlierberghe, P. / Lasters, I. / Savvides, S.N.
External linksSci Adv / PubMed:33771865
MethodsX-ray diffraction
Resolution2.3 - 3.272 Å
Structure data

PDB-6zie:
Crystal structure of MCL-1 in complex with a neutralizing Alphabody CMPX-383B
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6zl1:
Crystal structure of human serum albumin in complex with the MCL-1 neutralizing Alphabody CMPX-383B
Method: X-RAY DIFFRACTION / Resolution: 3.272 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / de novo protein design / 3 helical antiparallel coiled coil / cell penetrating Alphabody MCL-1 neutralizing Alphabody / DE NOVO PROTEIN

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