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TitleThe actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity.
Journal, issue, pagesNat Commun, Vol. 12, Issue 1, Page 1892, Year 2021
Publish dateMar 25, 2021
AuthorsJulien Robert-Paganin / Xiao-Ping Xu / Mark F Swift / Daniel Auguin / James P Robblee / Hailong Lu / Patricia M Fagnant / Elena B Krementsova / Kathleen M Trybus / Anne Houdusse / Niels Volkmann / Dorit Hanein /
PubMed AbstractPlasmodium falciparum, the causative agent of malaria, moves by an atypical process called gliding motility. Actomyosin interactions are central to gliding motility. However, the details of these ...Plasmodium falciparum, the causative agent of malaria, moves by an atypical process called gliding motility. Actomyosin interactions are central to gliding motility. However, the details of these interactions remained elusive until now. Here, we report an atomic structure of the divergent Plasmodium falciparum actomyosin system determined by electron cryomicroscopy at the end of the powerstroke (Rigor state). The structure provides insights into the detailed interactions that are required for the parasite to produce the force and motion required for infectivity. Remarkably, the footprint of the myosin motor on filamentous actin is conserved with respect to higher eukaryotes, despite important variability in the Plasmodium falciparum myosin and actin elements that make up the interface. Comparison with other actomyosin complexes reveals a conserved core interface common to all actomyosin complexes, with an ancillary interface involved in defining the spatial positioning of the motor on actin filaments.
External linksNat Commun / PubMed:33767187 / PubMed Central
MethodsEM (helical sym.)
Resolution3.77 Å
Structure data

11818

7aln

EMDB-11818, PDB-7aln:
Cryo-EM structure of the divergent actomyosin complex from Plasmodium falciparum Myosin A in the Rigor state
Method: EM (helical sym.) / Resolution: 3.77 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-9UE:
Jasplakinolide

Source
  • plasmodium falciparum (isolate 3d7) (eukaryote)
KeywordsMOTOR PROTEIN / Malaria / Plasmodium falciparum / Myosin A / invasion / Actin 1

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