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TitleReduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
Journal, issue, pagesCell, Vol. 184, Page 2201-, Year 2021
Publish dateFeb 4, 2021 (structure data deposition date)
AuthorsSupasa, P. / Zhou, D. / Dejnirattisai, W. / Liu, C. / Mentzer, A.J. / Ginn, H.M. / Zhao, Y. / Duyvesteyn, H.M.E. / Nutalai, R. / Tuekprakhon, A. ...Supasa, P. / Zhou, D. / Dejnirattisai, W. / Liu, C. / Mentzer, A.J. / Ginn, H.M. / Zhao, Y. / Duyvesteyn, H.M.E. / Nutalai, R. / Tuekprakhon, A. / Wang, B. / Paesen, G.C. / Slon-Campos, J. / Lopez-Camacho, C. / Hallis, B. / Coombes, N. / Bewley, K.R. / Charlton, S. / Walter, T.S. / Barnes, E. / Dunachie, S.J. / Skelly, D. / Lumley, S.F. / Baker, N. / Shaik, I. / Humphries, H.E. / Godwin, K. / Gent, N. / Sienkiewicz, A. / Dold, C. / Levin, R. / Dong, T. / Pollard, A.J. / Knight, J.C. / Klenerman, P. / Crook, D. / Lambe, T. / Clutterbuck, E. / Bibi, S. / Flaxman, A. / Bittaye, M. / Belij-Rammerstorfer, S. / Gilbert, S. / Hall, D.R. / Williams, M.A. / Paterson, N.G. / James, W. / Carroll, M.W. / Fry, E.E. / Mongkolsapaya, J. / Ren, J. / Stuart, D.I. / Screaton, G.R.
External linksCell / PubMed:33743891
MethodsX-ray diffraction
Resolution1.77 - 2.19 Å
Structure data

PDB-7neg:
Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

PDB-7neh:
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NO3:
NITRATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / SARS-CoV-2 B.1.1.7 variant / N501Y mutation / antibody / receptor-binding-domain / spike / neutralisation / VIRAL PROTEIN-IMMUNE SYSTEM complex

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