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TitleA human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
Journal, issue, pagesNat Commun, Vol. 12, Page 1750-1750, Year 2021
Publish dateAug 20, 2020 (structure data deposition date)
AuthorsCoelho, C.H. / Tang, W.K. / Burkhardt, M. / Galson, J.D. / Muratova, O. / Salinas, N.D. / Alves E Silva, T.L. / Reiter, K. / MacDonald, N.J. / Nguyen, V. ...Coelho, C.H. / Tang, W.K. / Burkhardt, M. / Galson, J.D. / Muratova, O. / Salinas, N.D. / Alves E Silva, T.L. / Reiter, K. / MacDonald, N.J. / Nguyen, V. / Herrera, R. / Shimp, R. / Narum, D.L. / Byrne-Steele, M. / Pan, W. / Hou, X. / Brown, B. / Eisenhower, M. / Han, J. / Jenkins, B.J. / Doritchamou, J.Y.A. / Smelkinson, M.G. / Vega-Rodriguez, J. / Truck, J. / Taylor, J.J. / Sagara, I. / Renn, J.P. / Tolia, N.H. / Duffy, P.E.
External linksNat Commun / PubMed:33741942
MethodsX-ray diffraction
Resolution1.998 Å
Structure data

PDB-7jum:
Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01
Method: X-RAY DIFFRACTION / Resolution: 1.998 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum (isolate 3d7) (eukaryote)
  • homo sapiens (human)
KeywordsCELL INVASION / Pfs230D1 / Pfs230 / monoclonal antibody

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