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TitleIdentification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses.
Journal, issue, pagesCommun Biol, Vol. 4, Issue 1, Page 250, Year 2021
Publish dateFeb 26, 2021
AuthorsJustin W Flatt / Aušra Domanska / Alma L Seppälä / Sarah J Butcher /
PubMed AbstractEnteroviruses pose a persistent and widespread threat to human physical health, with no specific treatments available. Small molecule capsid binders have the potential to be developed as antivirals ...Enteroviruses pose a persistent and widespread threat to human physical health, with no specific treatments available. Small molecule capsid binders have the potential to be developed as antivirals that prevent virus attachment and entry into host cells. To aid with broad-range drug development, we report here structures of coxsackieviruses B3 and B4 bound to different interprotomer-targeting capsid binders using single-particle cryo-EM. The EM density maps are beyond 3 Å resolution, providing detailed information about interactions in the ligand-binding pocket. Comparative analysis revealed the residues that form a conserved virion-stabilizing network at the interprotomer site, and showed the small molecule properties that allow anchoring in the pocket to inhibit virus disassembly.
External linksCommun Biol / PubMed:33637854 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 3.4 Å
Structure data

11165

6zck

EMDB-11165, PDB-6zck:
Coxsackievirus B4 in complex with capsid binder compound 48
Method: EM (single particle) / Resolution: 2.7 Å

11166

6zcl

EMDB-11166, PDB-6zcl:
Coxsackievirus B3 in complex with capsid binder compound 17
Method: EM (single particle) / Resolution: 2.8 Å

11300

6zms

EMDB-11300, PDB-6zms:
Coxsackievirus B4 strain E2
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

ChemComp-QFW:
4-[(6-propoxynaphthalen-2-yl)sulfonylamino]benzoic acid

ChemComp-FHK:
4-[[4-[1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]sulfonylamino]benzoic acid

ChemComp-MYR:
MYRISTIC ACID / Myristic acid

Source
  • coxsackievirus b4 (strain e2)
  • coxsackievirus b3 (strain nancy)
KeywordsVIRUS / Enterovirus / Coxsackievirus B4 / Inhibitor / Capsid Binder / coxackievirus B4

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