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Structure paper

TitleKRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Journal, issue, pagesNat Commun, Vol. 12, Page 1176-1176, Year 2021
Publish dateJan 16, 2020 (structure data deposition date)
AuthorsTran, T.H. / Chan, A.H. / Young, L.C. / Bindu, L. / Neale, C. / Messing, S. / Dharmaiah, S. / Taylor, T. / Denson, J.P. / Esposito, D. ...Tran, T.H. / Chan, A.H. / Young, L.C. / Bindu, L. / Neale, C. / Messing, S. / Dharmaiah, S. / Taylor, T. / Denson, J.P. / Esposito, D. / Nissley, D.V. / Stephen, A.G. / McCormick, F. / Simanshu, D.K.
External linksNat Commun / PubMed:33608534
MethodsX-ray diffraction
Resolution1.4 - 2.87 Å
Structure data

PDB-6vjj:
Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-6xgu:
Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6xgv:
Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-6xha:
Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

PDB-6xhb:
Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-6xi7:
Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form I)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / KRAS / RAS / K-ras / KRAS4b / RAF1 / CRAF / RBD / RAS-binding domain / ONCOPROTEIN/Transferase / Q61R / cysteine-rich domain / CRD / ONCOPROTEIN-Transferase complex / G13D / G12V / Transferase/Hydrolase / Transferase-Hydrolase complex

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