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TitleCombining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody.
Journal, issue, pagesMabs, Vol. 13, Page 1883239-1883239, Year 2021
Publish dateNov 13, 2020 (structure data deposition date)
AuthorsCampbell, S.M. / DeBartolo, J. / Apgar, J.R. / Mosyak, L. / McManus, V. / Beyer, S. / Bennett, E.M. / Lambert, M. / Cunningham, O.
External linksMabs / PubMed:33557673
MethodsX-ray diffraction
Resolution2.203 Å
Structure data

PDB-7kq7:
Crystal structure of IL21R in complex with an antibody Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.203 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • homo sapiens (human)
KeywordsPROTEIN BINDING/Immune System / cytokine receptor / PROTEIN BINDING / PROTEIN BINDING-Immune System complex

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