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TitleSingle nucleotide variants lead to dysregulation of the human mitochondrial NAD(P) + -dependent malic enzyme.
Journal, issue, pagesIscience, Vol. 24, Page 102034-102034, Year 2021
Publish dateMar 30, 2020 (structure data deposition date)
AuthorsHsieh, J.Y. / Yang, H.P. / Tewary, S.K. / Cheng, H.C. / Liu, Y.L. / Tai, S.C. / Chen, W.L. / Hsu, C.H. / Huang, T.J. / Chou, C.J. ...Hsieh, J.Y. / Yang, H.P. / Tewary, S.K. / Cheng, H.C. / Liu, Y.L. / Tai, S.C. / Chen, W.L. / Hsu, C.H. / Huang, T.J. / Chou, C.J. / Huang, Y.N. / Peng, C.T. / Ho, M.C. / Liu, G.Y. / Hung, H.C.
External linksIscience / PubMed:33554057
MethodsX-ray diffraction
Resolution2.48 - 2.55 Å
Structure data

PDB-7bsj:
Crystal structure of human ME2 R484W
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

PDB-7bsk:
Crystal structure of human ME2 R67Q mutant
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-7bsl:
Crystal Structure of human ME2 R67A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-MG:
Unknown entry

ChemComp-FUM:
FUMARIC ACID

ChemComp-TTN:
TARTRONATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / malate dehydrogenase / NAD-dependent malic enzyme

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