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TitleStructure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.
Journal, issue, pagesBlood, Vol. 137, Page 2981-2986, Year 2021
Publish dateSep 18, 2020 (structure data deposition date)
AuthorsGish, J.S. / Jarvis, L. / Childers, K.C. / Peters, S.C. / Garrels, C.S. / Smith, I.W. / Spencer, H.T. / Doering, C.B. / Lollar, P. / Spiegel, P.C.
External linksBlood / PubMed:33529335
MethodsX-ray diffraction
Resolution3.92 Å
Structure data

PDB-7k66:
Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.92 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CU:
COPPER (II) ION

ChemComp-CA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsBLOOD CLOTTING/Immune System / Antibody / inhibitor / BLOOD CLOTTING / BLOOD CLOTTING-Immune System complex

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