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Structure paper

TitleUnique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Journal, issue, pagesNat Commun, Vol. 12, Page 559-559, Year 2021
Publish dateApr 3, 2020 (structure data deposition date)
AuthorsHarshbarger, W.D. / Deming, D. / Lockbaum, G.J. / Attatippaholkun, N. / Kamkaew, M. / Hou, S. / Somasundaran, M. / Wang, J.P. / Finberg, R.W. / Zhu, Q.K. ...Harshbarger, W.D. / Deming, D. / Lockbaum, G.J. / Attatippaholkun, N. / Kamkaew, M. / Hou, S. / Somasundaran, M. / Wang, J.P. / Finberg, R.W. / Zhu, Q.K. / Schiffer, C.A. / Marasco, W.A.
External linksNat Commun / PubMed:33495478
MethodsX-ray diffraction
Resolution3.21 - 4.19 Å
Structure data

PDB-6wex:
Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H6 Hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 3.49 Å

PDB-6wez:
Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H3 Hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

PDB-6wf0:
Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H3 Hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 3.46 Å

PDB-6wf1:
Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H10 Hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 4.19 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

Source
  • influenza a virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Antibody / Influenza / Hemagglutinin / Stem epitope / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex

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