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-Structure paper
Title | A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF. |
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Journal, issue, pages | Nat Commun, Vol. 12, Page 583-583, Year 2021 |
Publish date | Nov 10, 2020 (structure data deposition date) |
![]() | Lightwood, D.J. / Munro, R.J. / Porter, J. / McMillan, D. / Carrington, B. / Turner, A. / Scott-Tucker, A. / Hickford, E.S. / Schmidt, A. / Fox III, D. ...Lightwood, D.J. / Munro, R.J. / Porter, J. / McMillan, D. / Carrington, B. / Turner, A. / Scott-Tucker, A. / Hickford, E.S. / Schmidt, A. / Fox III, D. / Maloney, A. / Ceska, T. / Bourne, T. / O'Connell, J. / Lawson, A.D.G. |
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Methods | X-ray diffraction |
Resolution | 2.3 - 3 Å |
Structure data | ![]() PDB-7kpa: ![]() PDB-7kpb: |
Chemicals | ![]() ChemComp-D84: ![]() ChemComp-HOH: ![]() ChemComp-GOL: ![]() ChemComp-NAG: |
Source |
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![]() | CYTOKINE / TNF / Receptor / TNFR1 / symmetric / CYTOKINE/Immune System / Tumour necrosis factor alpha / asymmetric / protein-protein inhibitor / Fragment antibody / Fab / CYTOKINE-Immune System complex |