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TitleA conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.
Journal, issue, pagesNat Commun, Vol. 12, Page 583-583, Year 2021
Publish dateNov 10, 2020 (structure data deposition date)
AuthorsLightwood, D.J. / Munro, R.J. / Porter, J. / McMillan, D. / Carrington, B. / Turner, A. / Scott-Tucker, A. / Hickford, E.S. / Schmidt, A. / Fox III, D. ...Lightwood, D.J. / Munro, R.J. / Porter, J. / McMillan, D. / Carrington, B. / Turner, A. / Scott-Tucker, A. / Hickford, E.S. / Schmidt, A. / Fox III, D. / Maloney, A. / Ceska, T. / Bourne, T. / O'Connell, J. / Lawson, A.D.G.
External linksNat Commun / PubMed:33495445
MethodsX-ray diffraction
Resolution2.3 - 3 Å
Structure data

PDB-7kpa:
asymmetric hTNF-alpha
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-7kpb:
Human TNF-alpha TNFR1 complex bound to conformationally selective antibody
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-D84:
5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsCYTOKINE / TNF / Receptor / TNFR1 / symmetric / CYTOKINE/Immune System / Tumour necrosis factor alpha / asymmetric / protein-protein inhibitor / Fragment antibody / Fab / CYTOKINE-Immune System complex

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