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-Structure paper
Title | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. |
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Journal, issue, pages | Nat Commun, Vol. 12, Page 582-582, Year 2021 |
Publish date | Nov 10, 2020 (structure data deposition date) |
![]() | McMillan, D. / Martinez-Fleites, C. / Porter, J. / Fox 3rd, D. / Davis, R. / Mori, P. / Ceska, T. / Carrington, B. / Lawson, A. / Bourne, T. / O'Connell, J. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.15 - 3.15 Å |
Structure data | ![]() PDB-7kp7: ![]() PDB-7kp8: ![]() PDB-7kp9: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-NAG: ![]() ChemComp-HOH: ![]() ChemComp-A7G: |
Source |
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![]() | CYTOKINE / Tumour necrosis factor alpha / TNF / Receptor / TNFR1 / asymmetric / protein-protein inhibitor |