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TitleSelective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
Publish dateNov 16, 2020 (structure data deposition date)
AuthorsXiao, X. / Kim, Y. / Romartinez-Alonso, B. / Sirvydis, K. / Ory, D.S. / Schwabe, J.W.R. / Jung, M.E. / Tontonoz, P.
External linksProc. Natl. Acad. Sci. USA / PubMed:33376205
MethodsX-ray diffraction
Resolution2.09 Å
Structure data

PDB-7azn:
Structure of mouse AsterC (GramD1c) with a new cholesterol-derived compound
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-YK8:
20alpha-hydroxy-20-(5-methylhexyl)cholesterol

ChemComp-EOH:
ETHANOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsLIPID TRANSPORT / Non vesicular cholesterol transport / lipid-binding / endoplasmic reticulum / membrane contact sites

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