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TitleHow to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine.
Journal, issue, pagesMolecules, Vol. 25, Year 2020
Publish dateMar 18, 2015 (structure data deposition date)
AuthorsWurzlbauer, A. / Ruben, K. / Gurdal, E. / Chaikuad, A. / Knapp, S. / Sippl, W. / Becker, W. / Bracher, F.
External linksMolecules / PubMed:33339338
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-4yu2:
Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-4H5:
(1-chloro-7-methoxy-9H-beta-carbolin-9-yl)acetonitrile

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / DYRK1A / down syndrome / inhibitor / harmine / Structural Genomics / Structural Genomics Consortium / SGC

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