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TitleTargeting the myeloid checkpoint receptor SIRP alpha potentiates innate and adaptive immune responses to promote anti-tumor activity.
Journal, issue, pagesJ Hematol Oncol, Vol. 13, Page 160-160, Year 2020
Publish dateNov 11, 2020 (structure data deposition date)
AuthorsKuo, T.C. / Chen, A. / Harrabi, O. / Sockolosky, J.T. / Zhang, A. / Sangalang, E. / Doyle, L.V. / Kauder, S.E. / Fontaine, D. / Bollini, S. ...Kuo, T.C. / Chen, A. / Harrabi, O. / Sockolosky, J.T. / Zhang, A. / Sangalang, E. / Doyle, L.V. / Kauder, S.E. / Fontaine, D. / Bollini, S. / Han, B. / Fu, Y.X. / Sim, J. / Pons, J. / Wan, H.I.
External linksJ Hematol Oncol / PubMed:33256806
MethodsX-ray diffraction
Resolution2.27 Å
Structure data

PDB-7kpg:
Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / SIRPa antibody complex / signal regulatory protein alpha variant 1

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