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TitleDiscovery of Marburg virus neutralizing antibodies from virus-naive human antibody repertoires using large-scale structural predictions.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 31142-31148, Year 2020
Publish dateNov 28, 2019 (structure data deposition date)
AuthorsBozhanova, N.G. / Sangha, A.K. / Sevy, A.M. / Gilchuk, P. / Huang, K. / Nargi, R.S. / Reidy, J.X. / Trivette, A. / Carnahan, R.H. / Bukreyev, A. ...Bozhanova, N.G. / Sangha, A.K. / Sevy, A.M. / Gilchuk, P. / Huang, K. / Nargi, R.S. / Reidy, J.X. / Trivette, A. / Carnahan, R.H. / Bukreyev, A. / Crowe Jr., J.E. / Meiler, J.
External linksProc. Natl. Acad. Sci. USA / PubMed:33229516
MethodsX-ray diffraction
Resolution1.39 - 3.48 Å
Structure data

PDB-6v4q:
Crystal structure of a MR78-like antibody naive-1 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.39 Å

PDB-6v4r:
Crystal structure of a chimeric MR78-like antibody chimera-1 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.48 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Marburg Virus / antibody

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