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TitleEngineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection.
Journal, issue, pagesCell Res, Vol. 31, Issue 1, Page 98-9100, Year 2021
Publish dateNov 11, 2020
AuthorsLiang Guo / Wenwen Bi / Xinling Wang / Wei Xu / Renhong Yan / Yuanyuan Zhang / Kai Zhao / Yaning Li / Mingfeng Zhang / Xia Cai / Shibo Jiang / Youhua Xie / Qiang Zhou / Lu Lu / Bobo Dang /
External linksCell Res / PubMed:33177651 / PubMed Central
MethodsEM (single particle)
Resolution4.0 - 4.3 Å
Structure data

30460

7ct5

EMDB-30460: cryo EM map of the S protein of SARS-CoV-2 in complex bound with T-ACE2
PDB-7ct5: S protein of SARS-CoV-2 in complex bound with T-ACE2
Method: EM (single particle) / Resolution: 4.0 Å

EMDB-30461:
cryo EM map of the interface between RBD of SARS-CoV-2 and T-ACE2
Method: EM (single particle) / Resolution: 4.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / S-ECD / ACE2

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