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Structure paper

TitleStructure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 29595-29601, Year 2020
Publish dateJun 14, 2020 (structure data deposition date)
AuthorsSobala, L.F. / Fernandes, P.Z. / Hakki, Z. / Thompson, A.J. / Howe, J.D. / Hill, M. / Zitzmann, N. / Davies, S. / Stamataki, Z. / Butters, T.D. ...Sobala, L.F. / Fernandes, P.Z. / Hakki, Z. / Thompson, A.J. / Howe, J.D. / Hill, M. / Zitzmann, N. / Davies, S. / Stamataki, Z. / Butters, T.D. / Alonzi, D.S. / Williams, S.J. / Davies, G.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:33154157
MethodsX-ray diffraction
Resolution1.09 - 3 Å
Structure data

PDB-6zdc:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with nickel
Method: X-RAY DIFFRACTION / Resolution: 2.251 Å

PDB-6zdf:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with HEPES
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-6zdk:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with HEPES and hexatungstotellurate(VI) TEW
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6zdl:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcIFG and hexatungstotellurate(VI) TEW
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6zfa:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcIFG, alpha-1,2-mannobiose and hexatungstotellurate(VI) TEW
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6zfn:
Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with 1-methyl alpha-1,2-mannobiose
Method: X-RAY DIFFRACTION / Resolution: 1.1 Å

PDB-6zfq:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with bis-tris
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-6zj1:
Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with tetrasaccharide N-glycan fragment and hexatungstotellurate(VI) TEW
Method: X-RAY DIFFRACTION / Resolution: 1.957 Å

PDB-6zj5:
Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcDMJ and hexatungstotellurate(VI) TEW
Method: X-RAY DIFFRACTION / Resolution: 2.269 Å

PDB-6zj6:
Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with cyclohexylmethyl-Glc-1,3-isofagomine
Method: X-RAY DIFFRACTION / Resolution: 1.09 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-MG:
Unknown entry

ChemComp-TEW:
6-tungstotellurate(VI)

ChemComp-IFM:
5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-DMJ:
1-DEOXYMANNOJIRIMYCIN

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-QTE:
methylcyclohexane

Source
  • homo sapiens (human)
  • bacteroides xylanisolvens xb1a (bacteria)
KeywordsHYDROLASE / Golgi / mannosidase / retaining

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