タイトル | Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. |
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ジャーナル・号・ページ | Science, Vol. 371, Year 2021 |
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掲載日 | 2020年5月5日 (構造データの登録日) |
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著者 | Liu, S. / Li, S. / Shen, G. / Sukumar, N. / Krezel, A.M. / Li, W. |
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リンク | Science / PubMed:33154105 |
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手法 | X線回折 |
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解像度 | 1.99 - 3.35 Å |
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構造データ | PDB-6wv3: Human VKOR with warfarin 手法: X-RAY DIFFRACTION / 解像度: 2.197 Å PDB-6wv4: Human VKOR C43S with warfarin 手法: X-RAY DIFFRACTION / 解像度: 3.012 Å PDB-6wv5: Human VKOR C43S mutant with vitamin K1 epoxide 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-6wv6: Human VKOR with phenindione 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6wv7: Human VKOR with Chlorophacinone 手法: X-RAY DIFFRACTION / 解像度: 2.483 Å PDB-6wv8: Takifugu rubripes VKOR-like C138S mutant with vitamin K1 手法: X-RAY DIFFRACTION / 解像度: 3.01 Å PDB-6wv9: Takifugu rubripes VKOR-like with vitamin K1 in noncatalytic state 手法: X-RAY DIFFRACTION / 解像度: 3.35 Å PDB-6wva: Takifugu rubripes VKOR-like with vitamin K1 epoxide at non-catalytic state 手法: X-RAY DIFFRACTION / 解像度: 3.35 Å PDB-6wvb: Takifugu rubripes VKOR-like with warfarin 手法: X-RAY DIFFRACTION / 解像度: 2.872 Å PDB-6wvh: Human VKOR with Brodifacoum 手法: X-RAY DIFFRACTION / 解像度: 1.99 Å PDB-6wvi: VKOR-like from Takifugu rubripes 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å |
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化合物 | ChemComp-UAV: (2R,3R)-2-hydroxy-3-methyl-2-[(2E,7S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-2,3-dihydronaphthalene-1,4-dione
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由来 | - aequorea victoria (オワンクラゲ)
- homo sapiens (ヒト)
- escherichia virus rb43 (ウイルス)
- takifugu rubripes (トラフグ)
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キーワード | OXIDOREDUCTASE / FLUORESCENT PROTEIN / Vitamin K epoxide Reductase (VKOR) / Vitamin K / warfarin / superwarfarin / vitamin K expoxide(KO) / membrane protein / phenindione / Chlorophacinone / Vitamin K epoxide Reductase / VKOR / VKOR-like protein / VKORL / Brodifacoum / vitamin K expoxide / KO |
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