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Structure paper

TitleA highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 18379-18389, Year 2020
Publish dateDec 20, 2019 (structure data deposition date)
AuthorsStefano, J.E. / Lord, D.M. / Zhou, Y. / Jaworski, J. / Hopke, J. / Travaline, T. / Zhang, N. / Wong, K. / Lennon, A. / He, T. ...Stefano, J.E. / Lord, D.M. / Zhou, Y. / Jaworski, J. / Hopke, J. / Travaline, T. / Zhang, N. / Wong, K. / Lennon, A. / He, T. / Bric-Furlong, E. / Cherrie, C. / Magnay, T. / Remy, E. / Brondyk, W. / Qiu, H. / Radosevic, K.
External linksJ. Biol. Chem. / PubMed:33122192
MethodsX-ray diffraction
Resolution2.25 - 3.73 Å
Structure data

PDB-6vc9:
TB19 complex
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-6vca:
TB38 complex
Method: X-RAY DIFFRACTION / Resolution: 3.73 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab / Enzyme

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