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-Structure paper
Title | Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 30, Page 127602-127602, Year 2020 |
Publish date | Sep 23, 2020 (structure data deposition date) |
Authors | Xu, G. / Gaul, M.D. / Liu, Z. / DesJarlais, R.L. / Qi, J. / Wang, W. / Krosky, D. / Petrounia, I. / Milligan, C.M. / Hermans, A. ...Xu, G. / Gaul, M.D. / Liu, Z. / DesJarlais, R.L. / Qi, J. / Wang, W. / Krosky, D. / Petrounia, I. / Milligan, C.M. / Hermans, A. / Lu, H.R. / Huang, D.Z. / Xu, J.Z. / Spurlino, J.C. |
External links | Bioorg. Med. Chem. Lett. / PubMed:33038544 |
Methods | X-ray diffraction |
Resolution | 2.539 - 2.60608692764 Å |
Structure data | PDB-7k7l: PDB-7k7z: |
Chemicals | ChemComp-MG: ChemComp-W4D: ChemComp-W4G: |
Source |
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Keywords | SIGNALING PROTEIN / TRANSFERASE/INHIBITOR / serine/threonine protein kinase / TRANSFERASE-INHIBITOR complex |