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TitleBinding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2.
Journal, issue, pagesViruses, Vol. 12, Issue 10, Year 2020
Publish dateSep 25, 2020
AuthorsMarc-André Hograindleur / Gregory Effantin / Daphna Fenel / Caroline Mas / André Lieber / Guy Schoehn / Pascal Fender / Emilie Vassal-Stermann /
PubMed AbstractThe study of viruses causing acute respiratory distress syndromes (ARDS) is more essential than ever at a time when a virus can create a global pandemic in a matter of weeks. Among human ...The study of viruses causing acute respiratory distress syndromes (ARDS) is more essential than ever at a time when a virus can create a global pandemic in a matter of weeks. Among human adenoviruses, adenovirus of serotype 7 (HAdV7) is one of the most virulent serotypes. This virus regularly re-emerges in Asia and has just been the cause of several deaths in the United States. A critical step of the virus life cycle is the attachment of the knob domain of the fiber (HAd7K) to the cellular receptor desmoglein-2 (DSG2). Complexes between the fiber knob and two extracellular domains of DSG2 have been produced. Their characterization by biochemical and biophysical methods show that these two domains are sufficient for the interaction and that the trimeric HAd7K could accommodate up to three DSG2 receptor molecules. The cryo-electron microscopy (cryo-EM) structure of these complexes at 3.1 Å resolution confirmed the biochemical data, and allowed the identification of the critical amino acid residues for this interaction, which shows similarities with other DSG2 interacting adenoviruses, despite a low homology in the primary sequences.
External linksViruses / PubMed:32992715 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.3 Å
Structure data

11778

7agf

EMDB-11778, PDB-7agf:
HAd7 knob in complex with 3 EC2-EC3 modules of DSG-2
Method: EM (single particle) / Resolution: 3.1 Å

11779

7agg

EMDB-11779, PDB-7agg:
HAd7 knob in complex with 2 EC2-EC3 modules of DSG-2
Method: EM (single particle) / Resolution: 3.3 Å

Source
  • homo sapiens (human)
  • human adenovirus b serotype 7
KeywordsVIRAL PROTEIN / adenovirus / cell receptor / complex

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