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TitleDiscovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody.
Journal, issue, pagesJ Alzheimers Dis, Vol. 77, Page 1397-1416, Year 2020
Publish dateJun 28, 2020 (structure data deposition date)
AuthorsVan Kolen, K. / Malia, T.J. / Theunis, C. / Nanjunda, R. / Teplyakov, A. / Ernst, R. / Wu, S.J. / Luo, J. / Borgers, M. / Vandermeeren, M. ...Van Kolen, K. / Malia, T.J. / Theunis, C. / Nanjunda, R. / Teplyakov, A. / Ernst, R. / Wu, S.J. / Luo, J. / Borgers, M. / Vandermeeren, M. / Bottelbergs, A. / Wintmolders, C. / Lacy, E. / Maurin, H. / Larsen, P. / Willems, R. / Van De Casteele, T. / Triana-Baltzer, G. / Slemmon, R. / Galpern, W. / Trojanowski, J.Q. / Sun, H. / Mercken, M.H.
External linksJ Alzheimers Dis / PubMed:32894244
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-6xli:
CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IMMUNOGLOBULIN FOLD / ANTIBODY / NEUROSCIENCE

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