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Structure paper

TitleStructural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Journal, issue, pagesMabs, Vol. 12, Page 1801230-1801230
Publish dateSep 6, 2019 (structure data deposition date)
AuthorsAustin, M. / Burschowsky, D. / Chan, D.T.Y. / Jenkinson, L. / Haynes, S. / Diamandakis, A. / Seewooruthun, C. / Addyman, A. / Fiedler, S. / Ryman, S. ...Austin, M. / Burschowsky, D. / Chan, D.T.Y. / Jenkinson, L. / Haynes, S. / Diamandakis, A. / Seewooruthun, C. / Addyman, A. / Fiedler, S. / Ryman, S. / Whitehouse, J. / Slater, L.H. / Hadjinicolaou, A.V. / Gileadi, U. / Gowans, E. / Shibata, Y. / Barnard, M. / Kaserer, T. / Sharma, P. / Luheshi, N.M. / Wilkinson, R.W. / Vaughan, T.J. / Holt, S.V. / Cerundolo, V. / Carr, M.D. / Groves, M.A.T.
External linksMabs / PubMed:32880207
MethodsX-ray diffraction
Resolution1.7 - 2.9 Å
Structure data

PDB-6srv:
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021144
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6srx:
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021158
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6ss0:
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021181
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6ss2:
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6ss4:
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6tul:
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021177
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-SIN:
SUCCINIC ACID

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-GOL:
GLYCEROL

ChemComp-MN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-PO4:
PHOSPHATE ION

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-MLT:
D-MALATE

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / arginase-2 inhibitor / IgG / antigen-binding fragment

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