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TitleDual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.
Journal, issue, pagesMol. Cancer Ther., Vol. 19, Page 2126-2138, Year 2020
Publish dateOct 11, 2019 (structure data deposition date)
AuthorsOverdijk, M.B. / Strumane, K. / Beurskens, F.J. / Ortiz Buijsse, A. / Vermot-Desroches, C. / Vuillermoz, B.S. / Kroes, T. / de Jong, B. / Hoevenaars, N. / Hibbert, R.G. ...Overdijk, M.B. / Strumane, K. / Beurskens, F.J. / Ortiz Buijsse, A. / Vermot-Desroches, C. / Vuillermoz, B.S. / Kroes, T. / de Jong, B. / Hoevenaars, N. / Hibbert, R.G. / Lingnau, A. / Forssmann, U. / Schuurman, J. / Parren, P.W.H.I. / de Jong, R.N. / Breij, E.C.W.
External linksMol. Cancer Ther. / PubMed:32847982
MethodsX-ray diffraction
Resolution3.05 Å
Structure data

PDB-6t3j:
Dual Epitope Targeting by Anti-DR5 Antibodies
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / DR5 / ANTIBODY

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