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-Structure paper
Title | An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. |
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Journal, issue, pages | Sci. Signal., Vol. 13, Year 2020 |
Publish date | Aug 30, 2018 (structure data deposition date) |
Authors | Gannam, Z.T.K. / Min, K. / Shillingford, S.R. / Zhang, L. / Herrington, J. / Abriola, L. / Gareiss, P.C. / Pantouris, G. / Tzouvelekis, A. / Kaminski, N. ...Gannam, Z.T.K. / Min, K. / Shillingford, S.R. / Zhang, L. / Herrington, J. / Abriola, L. / Gareiss, P.C. / Pantouris, G. / Tzouvelekis, A. / Kaminski, N. / Zhang, X. / Yu, J. / Jamali, H. / Ellman, J.A. / Lolis, E. / Anderson, K.S. / Bennett, A.M. |
External links | Sci. Signal. / PubMed:32843541 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-6mc1: |
Chemicals | ChemComp-CJA: ChemComp-DTT: ChemComp-ACT: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / phosphatase / protein-tyrosine phosphatase / dual specificity phosphatase / phosphatase-inhibitor complex / HYDROLASE-HYDROLASE Inhibitor complex |