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Structure paper

TitleStructural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
Journal, issue, pagesInt J Mol Sci, Vol. 21, Year 2020
Publish dateJul 15, 2020 (structure data deposition date)
AuthorsSillen, M. / Weeks, S.D. / Strelkov, S.V. / Declerck, P.J.
External linksInt J Mol Sci / PubMed:32824134
MethodsX-ray diffraction
Resolution1.88 Å
Structure data

PDB-6zrv:
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93)
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • vicugna pacos (alpaca)
KeywordsHYDROLASE / plasminogen activator inhibitor-1 / PAI-1 / PAI-1-W175F / serpin / serine protease inhibitor / nanobody / antibody fragment / protein complex

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