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| Title | Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 63, Page 10061-10085, Year 2020 |
| Publish date | Oct 2, 2019 (structure data deposition date) |
 Authors | Smil, D. / Wong, J.F. / Williams, E.P. / Adamson, R.J. / Howarth, A. / McLeod, D.A. / Mamai, A. / Kim, S. / Wilson, B.J. / Kiyota, T. ...Smil, D. / Wong, J.F. / Williams, E.P. / Adamson, R.J. / Howarth, A. / McLeod, D.A. / Mamai, A. / Kim, S. / Wilson, B.J. / Kiyota, T. / Aman, A. / Owen, J. / Poda, G. / Horiuchi, K.Y. / Kuznetsova, E. / Ma, H. / Hamblin, J.N. / Cramp, S. / Roberts, O.G. / Edwards, A.M. / Uehling, D. / Al-Awar, R. / Bullock, A.N. / O'Meara, J.A. / Isaac, M.B. |
 External links | J. Med. Chem. / PubMed:32787083 |
| Methods | X-ray diffraction |
| Resolution | 1.42 Å |
| Structure data |  PDB-6szm: |
| Chemicals |  ChemComp-M2Z:  ChemComp-SO4:  ChemComp-EDO:  ChemComp-NH4:  ChemComp-DMS:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN / KINASE / BMP / INHIBITOR / SIGNALLING |
homo sapiens (human)