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TitleAn alternate conformation of HCV E2 neutralizing face as an additional vaccine target.
Journal, issue, pagesSci Adv, Vol. 6, Page eabb5642-eabb5642, Year 2020
Publish dateApr 24, 2020 (structure data deposition date)
AuthorsTzarum, N. / Giang, E. / Kadam, R.U. / Chen, F. / Nagy, K. / Augestad, E.H. / Velazquez-Moctezuma, R. / Keck, Z.Y. / Hua, Y. / Stanfield, R.L. ...Tzarum, N. / Giang, E. / Kadam, R.U. / Chen, F. / Nagy, K. / Augestad, E.H. / Velazquez-Moctezuma, R. / Keck, Z.Y. / Hua, Y. / Stanfield, R.L. / Dreux, M. / Prentoe, J. / Foung, S.K.H. / Bukh, J. / Wilson, I.A. / Law, M.
External linksSci Adv / PubMed:32754640
MethodsX-ray diffraction
Resolution1.645 - 3.667 Å
Structure data

PDB-6wo3:
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody U1
Method: X-RAY DIFFRACTION / Resolution: 2.382 Å

PDB-6wo4:
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody HC11
Method: X-RAY DIFFRACTION / Resolution: 2.349 Å

PDB-6wo5:
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1
Method: X-RAY DIFFRACTION / Resolution: 2.619 Å

PDB-6woq:
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody HC1AM and non neutralizing antibody E1
Method: X-RAY DIFFRACTION / Resolution: 3.667 Å

PDB-6wor:
Structure of the broadly neutralizing antibody HC1AM
Method: X-RAY DIFFRACTION / Resolution: 2.601 Å

PDB-6wos:
Structure of broadly neutralizing antibody AR3B
Method: X-RAY DIFFRACTION / Resolution: 1.645 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-BMA:
beta-D-mannopyranose

Source
  • recombinant hepatitis c virus hk6a/jfh-1
  • homo sapiens (human)
  • hepatitis c virus (isolate h)
KeywordsIMMUNE SYSTEM/Viral Protein / HCV / broadly neutralizing antibodies / bNAbs / E2 core / IGHV1-69 / IMMUNE SYSTEM / IMMUNE SYSTEM-Viral Protein complex

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