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Structure paper

TitleRational design and implementation of a chemically inducible heterotrimerization system.
Journal, issue, pagesNat. Methods, Vol. 17, Page 928-936, Year 2020
Publish dateMar 9, 2020 (structure data deposition date)
AuthorsWu, H.D. / Kikuchi, M. / Dagliyan, O. / Aragaki, A.K. / Nakamura, H. / Dokholyan, N.V. / Umehara, T. / Inoue, T.
External linksNat. Methods / PubMed:32747768
MethodsX-ray diffraction
Resolution2.2 - 3.11 Å
Structure data

PDB-6m4u:
Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6m4v:
Crystal structure of MBP fused split FKBP in complex with rapamycin
Method: X-RAY DIFFRACTION / Resolution: 2.92 Å

PDB-6m4w:
Crystal structure of MBP fused split FKBP-FRB T2098L mutant in complex with rapamycin
Method: X-RAY DIFFRACTION / Resolution: 3.11 Å

Chemicals

ChemComp-RAP:
RAPAMYCIN IMMUNOSUPPRESSANT DRUG / immunosuppressant, antibiotic*YM

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • escherichia coli k-12 (bacteria)
KeywordsISOMERASE / Rapamycin / complex / kinase

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