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Structure paper

TitleIntrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
Journal, issue, pagesJCI Insight, Vol. 5, Year 2020
Publish dateOct 29, 2018 (structure data deposition date)
AuthorsLaffranchi, M. / Elliston, E.L. / Miranda, E. / Perez, J. / Ronzoni, R. / Jagger, A.M. / Heyer-Chauhan, N. / Brantly, M.L. / Fra, A. / Lomas, D.A. / Irving, J.A.
External linksJCI Insight / PubMed:32699193
MethodsX-ray diffraction
Resolution1.93 - 3.1 Å
Structure data

PDB-6i1o:
Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-6i3z:
Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NA:
Unknown entry

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Antibody fragment / Antitrypsin binding / Diagnostic / Monoclonal / selective / wild-type / Glu342 / E342

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