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Structure paper

TitleBiochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA.
Journal, issue, pagesNucleic Acids Res., Vol. 48, Page 10329-10341, Year 2020
Publish dateApr 1, 2020 (structure data deposition date)
AuthorsWoodcock, C.B. / Horton, J.R. / Zhou, J. / Bedford, M.T. / Blumenthal, R.M. / Zhang, X. / Cheng, X.
External linksNucleic Acids Res. / PubMed:32663306
MethodsX-ray diffraction
Resolution1.18 - 1.8 Å
Structure data

PDB-6we8:
YTH domain of human YTHDC1
Method: X-RAY DIFFRACTION / Resolution: 1.18 Å

PDB-6we9:
YTH domain of human YTHDC1 with 11mer ssDNA Containing N6mA
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

PDB-6wea:
YTH domain of human YTHDC1 with a 10mer Oligo Containing N6mA
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / N6-methyladenine binding protein domain / DNA BINDING PROTEIN/DNA / DNA BINDING PROTEIN-DNA complex / ssDNA

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