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Structure paper

TitleStructural Basis of Noscapine Activation for Tubulin Binding.
Journal, issue, pagesJ. Med. Chem., Vol. 63, Page 8495-8501, Year 2020
Publish dateFeb 26, 2020 (structure data deposition date)
AuthorsOliva, M.A. / Prota, A.E. / Rodriguez-Salarichs, J. / Bennani, Y.L. / Jimenez-Barbero, J. / Bargsten, K. / Canales, A. / Steinmetz, M.O. / Diaz, J.F.
External linksJ. Med. Chem. / PubMed:32657585
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-6y6d:
Tubulin-7-Aminonoscapine complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-OBQ:
(3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
KeywordsCELL CYCLE / TUBULIN FOLD / CYTOSKELETON / MICROTUBULE

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