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Structure paper

TitleRepulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 15620-15631, Year 2020
Publish dateMay 20, 2020 (structure data deposition date)
AuthorsMalinauskas, T. / Peer, T.V. / Bishop, B. / Mueller, T.D. / Siebold, C.
External linksProc. Natl. Acad. Sci. USA / PubMed:32576689
MethodsX-ray diffraction
Resolution1.65 - 5.501 Å
Structure data

PDB-6z3g:
Repulsive Guidance Molecule A (RGMA) in complex with Growth Differentiation Factor 5 (GDF5)
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

PDB-6z3h:
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 2)
Method: X-RAY DIFFRACTION / Resolution: 3.158 Å

PDB-6z3j:
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-6z3l:
Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation Factor 5 (GDF5)
Method: X-RAY DIFFRACTION / Resolution: 2.513 Å

PDB-6z3m:
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1).
Method: X-RAY DIFFRACTION / Resolution: 5.501 Å

Chemicals

ChemComp-CIT:
CITRIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / Repulsive Guidance Molecule / RGM / Bone Morphogenetic Protein / BMP / Growth Differentiation Factor 5 / GDF5 / Neogenin / axon guidance / TGFbeta signalling / brain development / iron metabolism. / iron metabolism / Hemojuvelin / HJV / HFE2 / hemochromatosis type 2 protein / juvenile hemochromatosis.

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