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TitleProof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines.
Journal, issue, pagesSci Adv, Vol. 6, Page eaaz6225-eaaz6225, Year 2020
Publish dateNov 13, 2019 (structure data deposition date)
AuthorsHe, L. / Tzarum, N. / Lin, X. / Shapero, B. / Sou, C. / Mann, C.J. / Stano, A. / Zhang, L. / Nagy, K. / Giang, E. ...He, L. / Tzarum, N. / Lin, X. / Shapero, B. / Sou, C. / Mann, C.J. / Stano, A. / Zhang, L. / Nagy, K. / Giang, E. / Law, M. / Wilson, I.A. / Zhu, J.
External linksSci Adv / PubMed:32494617
MethodsX-ray diffraction
Resolution1.897 - 3.375 Å
Structure data

PDB-6uyd:
Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C
Method: X-RAY DIFFRACTION / Resolution: 1.897 Å

PDB-6uyf:
Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 6a bound to broadly neutralizing antibody AR3B
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-6uyg:
Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3A and non neutralizing antibody E1
Method: X-RAY DIFFRACTION / Resolution: 3.375 Å

PDB-6uym:
Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v6 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C
Method: X-RAY DIFFRACTION / Resolution: 2.848 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • hepatitis c virus (isolate h)
  • homo sapiens (human)
  • recombinant hepatitis c virus hk6a/jfh-1
  • streptococcus sp. (bacteria)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HCV / E2 core / Vaccine design / self-assembly nanoparticle / broadly neutralizing antibodies / bNAbs / VIRAL PROTEIN-IMMUNE SYSTEM complex / VIRAL PROEIN/IMMUNE SYSTEM / VIRAL PROEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM

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