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Structure paper

TitleA H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants.
Journal, issue, pagesCancers (Basel), Vol. 12, Year 2020
Publish dateMay 14, 2020 (structure data deposition date)
AuthorsHan, C.W. / Jeong, M.S. / Ha, S.C. / Jang, S.B.
External linksCancers (Basel) / PubMed:32486141
MethodsX-ray diffraction
Resolution1.957 - 2.516 Å
Structure data

PDB-7c3z:
The structure of class II tumor suppressor protein H-REV107
Method: X-RAY DIFFRACTION / Resolution: 1.957 Å

PDB-7c40:
MgGDP bound KRAS G12V
Method: X-RAY DIFFRACTION / Resolution: 2.516 Å

PDB-7c41:
KRAS G12V and H-REV107 peptide complex
Method: X-RAY DIFFRACTION / Resolution: 2.276 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / H-REV107 / HREV107 type II tumor suppressor gene / retinoid-inducible gene 1 / ONCOPROTEIN / KRAS / mutant / G12V / MgGDP / STRUCTURAL PROTEIN / ONCOPROTEIN/HYDROLASE / KRAS G12V / inhibitor / ONCOPROTEIN-HYDROLASE complex

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