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Structure paper

TitleMolecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
Journal, issue, pagesJ Mol Cell Biol, Vol. 12, Page 741-744, Year 2020
Publish dateMar 31, 2020 (structure data deposition date)
AuthorsZhang, C. / Liu, Y. / Zhang, Y. / Wang, X. / Zhang, T. / Ding, J.
External linksJ Mol Cell Biol / PubMed:32470140
MethodsX-ray diffraction
Resolution2 - 2.6 Å
Structure data

PDB-7bta:
Crystal structure of Rheb D60K mutant bound to GDP
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7btc:
Crystal structure of Rheb Y35N mutant bound to GDP
Method: X-RAY DIFFRACTION / Resolution: 2.101 Å

PDB-7btd:
Crystal structure of Rheb Y35N mutant bound to GppNHp
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / mTORC1 / small GTPase / Rheb

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