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Structure paper

TitleStructural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus .
Journal, issue, pagesLife Sci Alliance, Vol. 3, Year 2020
Publish dateFeb 17, 2020 (structure data deposition date)
AuthorsHortschansky, P. / Misslinger, M. / Morl, J. / Gsaller, F. / Bromley, M.J. / Brakhage, A.A. / Groll, M. / Haas, H. / Huber, E.M.
External linksLife Sci Alliance / PubMed:32467317
MethodsX-ray diffraction
Resolution2.2 - 2.6 Å
Structure data

PDB-6y35:
CCAAT-binding complex from Aspergillus fumigatus with cycA DNA
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-6y36:
CCAAT-binding complex from Aspergillus fumigatus with cccA DNA
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6y37:
CCAAT-binding complex from Aspergillus nidulans with cccA DNA
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6y39:
HapE-P88L mutant CCAAT-binding complex from Aspergillus nidulans with cycA DNA
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-SO3:
SULFITE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

Source
  • neosartorya fumigata (strain atcc mya-4609 / af293 / cbs 101355 / fgsc a1100) (mold)
  • aspergillus fumigatus a1163 (mold)
  • aspergillus nidulans fgsc a4 (mold)
KeywordsTRANSCRIPTION / transcription factor / heterotrimer / histone fold / protein:DNA complex

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